Second JCA-AACR Special Joint Conference

The Latest Advances in Breast Cancer Research: From Basic Science to Therapeutics

July 14 -16, 2008
Awaji Yumebutai International Conference Center
The Westin Hotel Awaji Island, Hyogo, Japan

Organizing Committee:

JCA:

Yoshio Miki, Tokyo Medical and Dental University and the Cancer Institute of JFCR, Tokyo, Japan (Co-Chairperson)
Shinzaburo Noguchi, Osaka University, Osaka, Japan
Nobuyuki Hamajima, Nagoya University, Nagoya, Japan

AACR:

Carlos L. Arteaga, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA (Co- Chairperson)
Judy E. Garber, Dana-Farber Cancer Institute, Boston, MA, USA
Peter G. Shields, Lombardi Comprehensive Cancer Center, Washington, DC, USA

Show Details

MONDAY, July 14

Opening Remarks(12:50 pm - 1:00 pm)
Keynote Addresses(1:00 pm - 2:30 pm)

1. Title to be announced
   Joe W. Gray, Lawrence Berkeley National Laboratory (LBNL); Berkeley, CA, USA
2. Clinical Application of Molecular Diagnosis in Human Breast Cancers
   Shinzaburo Noguchi, Osaka University, Osaka, Japan

Session 1：Molecular Mechanisms of Breast Carcinogenesis,
DNA Repair, Epigenetics, etc.(2:30 p.m.- 4:15 p.m.)

1. Ubiquitin ligase activity of BRCA1 in breast cancer.
   Tomohiko Ohta, St. Marianna University, Kanagawa, Japan
2. Strong association between CpG island methylator phenotype and HER2 amplification in human breast cancers
   Toshikazu Ushijima, National Cancer Center Research Institute, Tokyo, Japan
3. Title to be announced
   Charlotte Kuperwasser, Tufts University, Boston, MA, USA

Session 2：Hormonal Carcinogenesis and Hormonal Therapy (4:45 p.m.-6:00 p.m.)

1. Estrogen signaling and response to hormonal therapy.
   Shinichi Hayashi, Tohoku University, Sendai, Japan
2. Title to be announced
   Myles A. Brown, Dana-Farber Cancer Institute, Boston, MA, USA

Poster Session A

TUESDAY, JULY 15

Session 3：Mechanism-based Translational Research for Cancer Detection, Diagnosis, and Intervention ( 8:30 a.m.-9:45 a.m.)

1. In vivo optical imaging of cancer and microenvironment
   Takeshi Imamura, Cancer Institute of JFCR, Tokyo, Japan
2. Title to be announced
   William Fraser Symmans, UT M. D. Anderson Cancer Cancer, Houston, TX, USA

Session 4：Novel Therapeutic ApproachesNovel Therapeutic Approaches(10:15 a.m. – 12:00 p.m.)

1. IGF-IR Inhibitors and PI3K Antagonists
   Carlos L. Arteaga, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA
2. Identification of PBK/TOPK, Ser/Thr protein kinase, as a druggable-target for breast cancer therapy though analysis of
3. genome-wide gene expression profile.
   Toyomasa Katagiri, Tokushima University, Tokushima, Japan Genetically engineered Bifidobacterium as a drug delivery system for systemic therapy of metastatic breast cancer patients
   Minoru Fujimori, Tokyo Medical University, Ibaragi, Japan

Session 5：Genomics, Proteomics and Biomarkers for Diagnosis,
Treatment, and Biology(1:00 p.m. – 2:45 p.m.)

1. Molecular diagnosis of response and adverse events to chemotherapy in breast cancer
   Yoshio Miki, Tokyo Medical and Dental University and the Cancer Institute of JFCR, Tokyo, Japan
2. Quantitation and Characterization of Circulating Tumor Cells
   Minetta C. Liu, Lombardi Comprehensive Cancer Center at Georgetown University, Washington, DC, USA
3. Post-transcriptional Gene Expression in Metastatic Breast Cancer
   Stephan Vagner, INSERM U563, Institut Claudius Regaud, Toulouse, France

Epidemiology and Genetics (Including New Breast Cancer Genes, Genetic Susceptibility and Cancer Risk)(3:15 p.m.- 5:45 p.m.)

1. Early Markers and Genetics for Sporadic Breast Cancer Risk
   Peter G. Shields, Lombardi Comprehensive Cancer Center, Washington, DC, USA
2. Hormone-related risk factors for breast cancer in Japanese women
   Chisato Nagata, Gifu University, Gifu, Japan
3. Title to be announced
   Nobuyuki Hamajima, Nagoya University, Nagoya, Japan
4. High-penetrance Genes
   Judy E. Garber, Dana-Farber Cancer Institute, Boston, MA, USA

Poster Session B

WEDNESDAY, JULY 16

Session 7：Stem cells and Intrinsic Subtype of Breast Cancer(8:30 a.m.-9:45 a.m.)

1. Chemoresistance in breast cancer stem-like cells
   Naoya Fujita, Cancer Chemotherapy Center of JFCR, Tokyo, Japan
2. Breast Cancer Stem Cells
   Christophe Ginestier, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA

Session 8：Gene mutation and oncogene signaling(10:15 a.m.-12:00 a.m.)

1. Oncogene Mediated Signal Transduction in Transgenic Mouse Models of Human Breast Cancer
   William J. Muller, McGill University, Royal Victoria Hospital, Montreal, QC, Canada
2. The EGFR-GEP100-Arf6 pathway in breast cancer: full invasiveness is not from the inside
3. Hisataka Sabe, Osaka Bioscience Institute, Osaka, Japan
   Title to be announced
   JCA SPEAKER

Closing Remarks

Poster presentations (Maximum: 50)

Conference office

Department of Molecular Genetics
Medical Research Institute
Tokyo Medical and Dental University
1-5-45 Yushima, Bunkyo-ku
Tokyo 113-8510, Japan
E-mail: jcaaacr.mgen@mri.tmd.ac.jp
Phone: +81-3-5803-5825, Fax: +81-3-5803-0242